Growth and differentiation factor 9 promotes oocyte growth at the primary but not the early secondary stage in three-dimensional follicle culture
نویسندگان
چکیده
منابع مشابه
O-20: The Combination of Basic Fibroblast Growth Factor and Follicular Stimulating Hormone Promotes Human Follicle Development In Vitro Culture
Background Fertility preservation is an important part of scientific study in the field of reproductive medicine. Ovarian cryopreservation and in vitro follicles culture provide option for fertility conservation in older women or cancer patients. Basic fibroblast growth factor (bFGF) or FGF-2, is member of fibroblast growth factors family which play critical roles in cell migration proliferatio...
متن کاملGrowth and differentiation factor-9 stimulates progression of early primary but not primordial rat ovarian follicle development.
The ovary contains a pool of primordial follicles containing oocytes arrested in meiosis that are the source of developing follicles for the female. Growth and differentiation factor-9 (GDF-9) is a member of the transforming growth factor beta superfamily of growth factors, and follicles of GDF-9 knockout mice arrest in the primary stage of development. The effect of GDF-9 treatment on the prim...
متن کاملInsulin but not insulin-like growth factor-1 promotes the primordial to primary follicle transition.
A critical step in ovarian biology is the transition of the developmentally arrested primordial follicle to the growing primary follicle. The current study utilizes a rat ovarian organ culture system to investigate the role of insulin and insulin-like growth factor-1 (IGF-1) in this process. Four-day-old rat ovaries were cultured and the degree of primordial to primary follicle transition measu...
متن کاملSecondary follicle growth and oocyte maturation during encapsulated three-dimensional culture in rhesus monkeys: effects of gonadotrophins, oxygen and fetuin.
BACKGROUND An alginate-based matrix supports the three-dimensional (3D) architecture of non-human primate follicles and, in the presence of FSH, permits the in vitro development of pre-antral follicles to the small antral stage, including the production of ovarian steroids and paracrine factors. The current study investigated the ability of gonadotrophins, fetuin and oxygen (O₂) to improve prim...
متن کاملGrowth differentiation factor 9 promotes rat preantral follicle growth by up-regulating follicular androgen biosynthesis.
The transition from preantral to early antral stage is the penultimate stage of ovarian follicular development in terms of gonadotropin dependence and follicle destiny. Although oocyte-somatic cell communication is important in early follicular development, our knowledge of the precise role of the oocyte-derived growth differentiation factor (GDF)-9 during preantral follicle growth is incomplet...
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ژورنال
عنوان ژورنال: Journal of Assisted Reproduction and Genetics
سال: 2016
ISSN: 1058-0468,1573-7330
DOI: 10.1007/s10815-016-0719-z